Function and genomic distribution of gene regulatory elements
Function of transcription factors
Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
Association of different modes of regulation with epigenetic marks and their inheritance
Transcriptional and translational regulation and dynamics in embryonic development
The role of core promoters and their diverse architectures in vertebrate development and differentiation
Emergence and evolutionary dynamics of conserved non-coding elements
Most of our work until now has been purely computational, either analysing publicly available data or in collaboration with experimental laboratories using high-throughput sequencing techniques such as CAGE, ATAC-seq, MNase-seq, RNA-seq, ChIP-seq and Hi-C. Since 2016 we also have experimental activity focusing on studying functional diversity of promoters in development and differentiation.